Testis and epididymis - Malakoplakia. This website is intended for pathologists and laboratory personnel but not for patients Definition / general. Rare histiocytic disease that occurs in all organs. Common in GU tract, particularly bladder. Also gastrointestinal tract (most commonly colon, followed by stomach and duodenum), central nervous system, female genital tract ( Radiographics 2006;26:1847 ) Single or multiple white-yellow soft raised plaques on the mucosal. Definition / general Rare chronic inflammatory / granulomatous disease that most commonly affects genitourinary tract (see topics in Bladder, Kidney, Prostate, Testis chapters) Usually in immunocompromised adult women due to inadequate phagocytosis / degradation of gram negative bacteria by macrophage
Spermatic cord tumors: aggressive / deep angiomyxoma leiomyoma (pending) leiomyosarcoma lipoma liposarcoma rhabdomyoma rhabdomyosarcoma. Other tumors: hemangioma lymphoma metastases myeloid sarcoma plasmacytoma. Disorders from other chapters: primary follicular lymphoma of testis. Testis stains: AFP CD30 CD117/KIT D2-40 Glypican 3 HCG inhibin. Malakoplakia of the testis. J. B. Blackwell. Department of Pathology, Royal Perth Hospital, Perth, Western Australia. Search for more papers by this author. J. B. Blackwell. Department of Pathology, Royal Perth Hospital, Perth, Western Australia. Search for more papers by this author Malakoplakia causes tubular destruction that is associated with a dense infiltrate of macrophages with granular eosinophilic cytoplasm that often contains Michaelis-Gutmann bodies (Fig. 12-160). 1534,1535 The differential diagnosis includes idiopathic granulo-matous orchitis and Leydig cell tumor
Idiopathic granulomatous orchitis is a rare inflammatory process of the testis of unknown etiology. It is characterized by presence of non-specific granulomatous inflammation and admixed multinucleated giant cells. It usually presents as a testicular mass which is highly suspicious of malignancy. Hi Malakoplakia. Diagnosis in short. Malakoplakia with numerous Michaelis-Gutmann bodies. H&E stain. LM. basophilic calcified bodies approximately the size of a RBC (Michaelis-Gutmann body) - inside or outside of macrophages, large foamy macrophages with granular cytoplasm +/- multinucleation, lymphocytes. LM DDx Malakoplakia is a chronic inflammatory disease characterized by tissue infiltrates of large granular macrophages containing distinctive intracytoplasmic inclusions termed Michaelis-Gutmann (MG) bodies. The genitourinary system is the most commonly involved site, followed by the gastrointestinal tract. Malakoplakia may occur as a complication of primary or secondary immunosuppression and.
Testis. Orchiectomy specimen showing testis replaced by tumour (proven to be seminoma ). (WC/Ed Uthman) The testis, plural testes, are important for survival of the species. Tumours occasionally arise in 'em. They generally are not biopsied. If the testis is biopsied, it is usually for fertility Malakoplakia of Testis. The tubular architecture is destroyed.The germ cells and Sertoli cells have been replaced with a dense infiltrate of macrophages containing granular eosinophilic cytoplasm. One of the characteristic features is the presence of Michelis-Gutman bodies which are round, targetoid, laminated structures Visual survey of surgical pathology with 11134 high-quality images of benign and malignant neoplasms & related entities. Webpathology.com: A Collection of Surgical Pathology Images Home Genitourinary Testis Inflammation Malakoplakia of Testis slide 8 of 29. Comments Visual survey of surgical pathology with 11131 high-quality images of benign and malignant neoplasms & related entities. Webpathology.com: A Collection of Surgical Pathology Images Malakoplakia of the testis has to be distinguished from idiopathic granulomatous orchitis and Leydig Cell Tumor. slide 10 of 29. Tweets by @WebPathology..
1. Orv Hetil. 1974 Jan 13;115(2):87-9. [Testicular malakoplakia]. [Article in Hungarian] Csapó Z, Gervain M. PMID: 4600796 [PubMed - indexed for MEDLINE Abstract. The chance finding of two cases of undiagnosed malakoplakia in the files of the Department of Pathology, Queen's University Belfast prompted a systematic study of all cases of inflammatory testicular and epididymal disease diagnosed in that department during a 43-year period from 1934 to 1977 Purpose: We reviewed histopathological studies of the testicular nubbins associated with the vanishing testis syndrome, and determined whether surgical removal is indicated based on the histological findings. Materials and methods: Between 1983 and 1997 a unilateral testicular nubbin consistent with a vanishing testis was excised in 29 patients an average of 28.6 months old Appendix testis. It consists of columnar epithelium enclosing a highly vascular fibrous core with smooth muscle cells. Invaginations of the surface may result in appearance of glandular structures in the core, as seen here. Due to its pedunculated structure, it may undergo hemorrhagic infarction causing severe testicular pain A decline in testicular function occurs normally with the aging process, matched by involutional changes in the testicular parenchyma, including hypospermatogenesis, peritubular fibrosis, and hyalinization of tubules commonly resulting in a pattern resembling that of mixed primary testicular pathology
Testicular atrophy. Diagnosis in short. Atrophic changes of the testis (bottom). H&E stain. Synonyms. atrophic testis, atrophy of the testis. LM. thickening of seminiferous tubule basement membrane, decreased sperm/no sperm present, +/-intertubular fibrosis. LM DDx WebPathology is a free educational resource with 11147 high quality pathology images of benign and malignant neoplasms and related entities. Visual survey of surgical pathology with 11147 high-quality images of benign and malignant neoplasms & related entities
The chance finding of two cases of undiagnosed malakoplakia in the files of the Department of Pathology, Queen's University Belfast prompted a systematic study of all cases of inflammatory testicular and epididymal disease diagnosed in that department during a 43-year period from 1934 to 1977. A total of 71 cases was studied, and no additional example of malakoplakia was found Malakoplakia is an uncommon inflammatory disorder which occurs most commonly in the urinary tract, but has also been reported in the prostate, testis, vagina, GI tract, lung, bone, brain, and skin. It is more common in females (ratio 4:1) and is more frequently seen in immunocompromised patients The chance finding of two cases of testicular malakoplakia in the files of the Department of Pathology, Queen's University Belfast prompted a systematic review of all cases of inflammatory and testicular disease in an attempt to discover further examplesofmalakoplakia. Theresults ofthisreview, detailedcasehistories, andhistopathologicalfinding
He has remained well in the 2 years following discharge. PATHOLOGY REPORT Gross appearance. The testis measured 5 by 3 by 3 cm. and had a thickened spermatic cord. The cut surface revealed along the outer 1 cm. of the testis a pale white homogeneous tissue which had extended into the spermatic cord for about 2 cm NEW FINE STRUCTURAL OBSERVATIONS IN TESTICULAR MALAKOPLAKIA Role of the Sertoli Cell G. PAUL DIONNE, M. D. E. G. BOVILL, M. D. THOMAS A. SEEMAYER, M.D., F.R.C.P.(C) From the Department of Pathology, Pathology Institute, McGill University, Royal Victoria Hospital, Montreal, Quebec, Canada ABSTRACT -A case of testicular malakoplakia is described in which cells other than histiocytes were.
To the Editor.—Yousef and Naghibi,1 in their recent review of malakoplakia, have a table of published reports of malakoplakia outside the urinary tract. In that table corresponding to testis, they list an article from 2002 by Répássy et al,2 which is a case report of malakoplakia involving the prostate gland. The introduction of the article by Répássy et al has an unreferenced. It can also occur, though less commonly, in the prostate, kidney, testis, lymph nodes, lungs, and bone. The typical mucosal lesion of malakoplakia is characterized by multiple yellow-brown, soft (malakos) plaques (plakos). Sometimes malakoplakia can form nodules or polypoid mass lesions, mimicking neoplasms malakoplakia cytology cytology in outline format with mouse over histology previews Pathology (1972), 4, pp. 311-14 INTESTINAL MALAKOPLAKIA: REPORT OF A CASE I . S. WILKEY and L. R. RUBEL Port Moresby General Hosfiital, Papua New Guinea and Armed Forces Institute of Pathology, Washington Summary Malakoplakia occurring in the terminal ileum, caecum, and attached mesentery of a Papuan woman is described A case of malakoplakia of the colon found in a 5 year old boy is reported. This condition is extremely rare in the intestine. Radiologically, the disease presented as polypoid lesions in the colon. Laparotomy disclosed several lobulated masses in the intestinal lumen along with lymph node enlargement. Microscopically numerous calcium containing concentrically laminated structures known as.
Malakoplakia is an acquired granulomatous disorder that was initially described in the bladder by Michaelis and Gutmann1 in 1902 and later by von Hansemann2 in 1903 who named the lesion malakoplakia meaning soft plaque. Since its initial description, more than 400 cases have been described in numerous anatomic locations including the bladder, kidney, prostate, testis, pancreas. Welcome to the updated version of Pathology for Urologists! This program was designed to help Urology residents and fellows familiarize themselves with the pathologic features of common urologic entities. This will serve not only as a resource tool for your review but also as a quick reference guide to urologic pathology EOSINOPHIOLIC HYALINE GLOBULES within and outside cytoplasm. 31 year old male felt an enlarged right testis. The testis was removed and there was a small soft reddish brown mass which microscopically had cords and sheets of primitive cells with large anaplastic cells with mitotic figures. The tumor is CK+; CD30+; PLAP+ Simple cysts of the testis are an uncommon lesion found in adults as well as infants. Only a few histological and immunohistochemical studies for this lesion have been reported because the lesion have rarely undergone surgical excision or histological confirmation. Herein is reported an autopsy case 738 J. C. DALE AND R. A. ROBINSON FIG. 1 Salivary gland tissue replaced by dense histiocytic infiltrate with occasional lymphocytes, plasma cells and ncutrophils. §&» FIG. 2 Dilated salivary duc filledt with bacteria and amorphous basophili
. Testicular pathology is a nosologically complex subject because of the spectrum of histologic subtypes and variable clinical behavior, particularly among GCTs. Prediction of biologic behavior depends upon. The Michaelis‐Gutmann (MG) inclusion bodies of three cases of malakoplakia (prostate, testis, colon) were studied by X‐ray microanalysis to determine their elemental composition. Calcium and phosphorus were consistently found. Iron was detected in a few bodies. No other elements were detected. The electrondense laminations were of similar composition to the core material. Small aggregates.
The Cram, acid-fast and Crocott stains were negative for micro-organisms (figs. 1 and 2). DISCUSSION Malakoplakia is more frequently located in the bladder but has been occasionally found in the ureters, renal pelvis and kidneys.4 Haukhol and Chinchinian reported a case of malakoplakia of the testicle.2 The present case involved the prostate Maria Carolina Reyes, MD. Assistant Professor of Clinical Pathology and Laboratory Medicine. University of Pennsylvania Perelman School of Medicine. Director of Surgical Pathology Fellowship. Contact Information 3400 Spruce Street. 2 Gates (room 15) Philadelphia, PA 19104. Office: 215-662-6503. Fax: 215-349-5910
Malakoplakia (from the Greek malacos, soft, and placos, plaques) is a rare granulomatous disease that occurs commonly in the urinary tract. It was first described by Michaelis and Gutmann in 1902. (1) Grossly, malakoplakia can present as soft tan yellow plaques and nodules or even extensive bands . The mass lesion seen here in the testis is a seminoma. Germ cell neoplasms are the most common types of testicular neoplasm. They are most common in the 15 to 34 age range. They may have more than one of several histologic components: seminoma, embryonal carcinoma, teratoma, choriocarcinoma Testicular LCTs can occur at any age but they are common in prepubertal boys (most often between 5 and 10 years of age) and in men aged 30 to 60 years.7,10 Leydig cell tumors are always benign in children, whereas in adults they are malignant in 10% of cases. Leydig cell tumors are hormonally active and considered as one of the steroid-secreting tumors Diagnostic Pathology: Genitourinary, 3rd Edition. Authors : Mahul B. Amin & Satish K. Tickoo. PREVIOUS EDITION -ISBN : 9780323377140. This item will be released on 12-27-2021. This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training alretinin immunohistochemically in nonneoplastic human ovaries and testes and ovarian sex cord-stromal tumors (SCSTs). In ovaries, calretinin was expressed in theca interna cells, hilus cells, and scattered individual stromal cells. Oocytes, granulosa cells, theca externa cells, rete ovarii, and most stromal cells were negative. Expression of calretinin was also seen in the ovarian surface.
The mysteries of malakoplakia. By Warren R. Heymann, MD. May 24, 2017. A, Dermal nodule with confluent sheets of histiocytes containing abundant granular amphophilic cytoplasm (arrows) admixed with an inflammatory infiltrate and scattered collection of neutrophils. B, Histiocytic inclusions staining positively for calcium on a von Kossa stain of malakoplakia with the first 6 patients in our institution, in this current case series we added 6 additional patients. Interestingly we have found malakoplakia in a diverse setting and heterogeneous patients, we found compromise in different organs such as testicle, kidney, prostate, bladder, ureters an Auto Text: Insert Testis Tumor or Insert Testis Benign Triage. Weigh specimen. Measure size of testis (3D) and length/diameter of spermatic cord. Ink tunica vaginalis. Cut through tunica vaginalis with scissors then bisect testis in the plane of the epididymis. Photograph cut surface. Measure tumor (3D) and document gross appearance
MALAKOPLAKIA OF KIDNEY SIMULATIN RENAL NEOPLASM A. TRILLO, M.D., PH. D. W. B. LORENTZ, M. D. N. O. WHITLEY, M.D. From the Departments of Pathology, Pediatrics, and Radiology, Bowman Gray School of Medicine of Wake Forest University, and North Carolina Baptist Hospital, Winston-Salem, North Carolina ABSTRACT - In a nine-year-old girl with renal hypertension and a urinary infection, angiographic. Testicular Biopsies in Male Infertility Huma Mushtaq1, Saeed Alam2 and Mumtaz Ahmad Khan3 1Assistant Professor, Department of Pathology, Islamabad Medical & Dental College, Islamabad 2Professor, Department of Pathology, This study outlines the differen . General information Frequently discussed syndromes Terms of dermatology Terms of hematology 2. Primary immunodeficiency disorders 3. Hemodynamic abnormalities Shock Thrombosis and embolism Bleeding disorders 4. Benign white cell disorders 5
Malakoplakia. Pathol Annu. 1981; 16(Pt 2):103-26 (ISSN: 0079-0184) Damjanov I; Katz SM. Major Subject Heading(s) Minor Subject Heading(s) Testicular Diseases [pathology] Testis [pathology] Urinary Bladder [pathology] Urinary Bladder Diseases [pathology] PreMedline Identifier: 7036058. cerebral malakoplakia which occurred in much younger patients and against a background of herpes simplex infection. Malakoplakia is an uncommon chronic inflam-matory lesion described originally by Michaelis and Gutmann.1 Thecondition is characterised morpho-logically by the appearance, within macrophages, of inclusions, the Michaelis-Gutmann. This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training.Covering all areas of genitourinary pathology, it incorporates the most recent clinical, pathological, staging, and molecular knowledge in the field to provide a comprehensive overview of all key issues relevant to today's practice Chicago, American Society of Clinical Pathology, 1966, pp 9-13. Google Scholar 32. Lambird PA, Yardley JH: Urinary tract malakoplakia: Report of a fatal case with ultrastructural observations of Michaelis-Gutman [sic] bodies. Johns Hopkins Med J 126: 1, 1970. PubMed CAS Google Scholar 33 The testis is the male gland responsible for sperm production. There is a fibrous capsule and multiple glands separated by a loose stoma. Within the glands there are mature and immature sperm. Within the stroma there are a few large Leydig cells which are responsible for testosterone production. 34-1
Seminoma. Diagnosis in short. Seminoma. H&E stain. LM. fried egg-like cells (clear or eosinophilic cytoplasm, central nucleus), lymphocytic infiltrate (common), +/- syncytiotrophoblasts (rare), +/-granulomas (uncommon) LM DDx. embryonal carcinoma, GCNIS, mixed germ cell tumour, granulomatous orchitis, testicular scar, atrophic testis. IHC pT1 - confined to the testis or epididymis, no lymphovascular invasion. pT2 - into tunica vaginalis or lymphovascular invasion. pT3 - into spermatic cord. pT4 - into the scrotum. Notes: Invasion into the epididymis and/or tunica albuginea does not change the stage. Rete testis involvement and testicular hilum involvement may be seen or. Normal fetal brown fat cells, medium power microscopic. Adrenal. Normal fetal adrenal gland, low power microscopic. Adrenal. Normal adult adrenal gland, low power microscopic. Aorta. Normal aorta, elastic tissue stain, low power microscopic. Appendix. Normal appendix, low power microscopic Epididymis Pathology outlines. Papillary cystadenocarcinoma of epididymis presenting with scrotal mass (J Urol 1992;147:162) Carcinoma of epididymis (Indian J Cancer 1973;10:475) Adenocarcinoma of the epididymis - 4 cases (Am J Surg Pathol 1997;21:1474) Primary adenocarcinoma of epididymis (Int Urol Nephrol 2004;36:77 Primary cause of epididymal obstruction Usually related to cystitis. Intratubular germ cell neoplasia, unclassified (IGCNU), is a precancerous lesion similar to carcinoma in situ for epithelial lesion. Fifty percent of patients with this condition will develop invasive germ cell tumors. In testicular biopsies for infertility, intratubular malignant germ cells are seen in 0.3-1.8% of cases
Prostate, nodular prostatic hyperplasia, urinary obstruction, diagram. Prostate, chips from transurethral resection of prostate (TURP), gross. Prostate with nodular hyperplasia, and bladder with hypertrophy and calculus. Bladder, with hypertrophy, gross. Prostate, nodular prostatic hyperplasia, low power microscopic The clinical and pathological features of 3 cases of colonic malakoplakia are documented thereby bringing to 34 the total of recorded cases of malakoplakia involving the gastrointestinal tract. This is therefore the most common site of involvement outside the urogenital tract. A comprehensive review of the world literature on gastrointestinal malakoplakia has been made and the characteristic. Malakoplakia is a rare granulomatous disease of infectious etiology that involves the skin and other organs. [1, 2] The name is derived from the Greek malakos (soft) and plakos (plaque), describing its usual clinical presentation as friable yellow soft plaques.It was first described by von Hansemann in 1901 and in 1902 by Michaelis and Gutmann The heart and arterial system. Central Nervous System Pathology: The brain and spinal cord. Endocrine Pathology: The thyroid, parathyroids, adrenal, pituitary, and endocrine pancreas. Female Genital Tract Pathology: The female reproductive system. Gastrointestinal Pathology: The digestive tract from esophagus to rectum
The biliary drain placement was performed to relieve a biliary stricture but the catheter was placed in the portal vein adjacent to the targeted bile duct resulting in hemoperitoneum. The end of the catheter was cut during removal of the liver as this was an unexpected finding at autopsy. Contributed by Mark A. Giffen, Jr., D.O Malakoplakia of the colon was a severe, debilitating illness in 2 patients and was fatal in 2 others. In the remaining 4 patients, it was an incidental finding associated with a carcinoma in 3 and an adenoma in 1. Histologic criteria for the diagnosis of malakoplakia have been discussed. Download to read the full article text A 47 year old Chinese man with diabetes mellitus and previously treated pulmonary tuberculosis presented with painless right testicular enlargement of 1 month's duration. He underwent an orchidectomy for presumed testicular neoplasm corroborated clinicoradiologically. Histological examination of the testicular mass revealed an inflammatory lesion comprising lymphocytes, plasma cells and. In adults, pure teratomas account for only 3-7% of GCTs (Mostofi et al. 1987 ). Postpubertal teratoma is a tumor component in nearly half of mixed GCTs (von Hochstetter and Hedinger 1982 ). It occurs in young adults. Male
Pathology is the precise study and diagnosis of disease. When a Clinical Pathologist looks at the cells from your orchiectomy or biopsy, they can determine what type of testicular cancer you have, if any. The report from the pathologist will determine the treatment you will receive. Staging is the process of finding out how far the cancer has. There are increasing reports of malakoplakia occurring outside its usual confines of the urinary tract, of which gastrointestinal tract is the most common location .Involvement of testis, and/or testicular adnexae is quite uncommon [2-5].Here it usually presents as a mass lesion, clinically and radiologically indistinguishable from testicular malignancy, as happened in this case
Cryptorchidism, also called cryptorchism, undescended testes, or undescended testicles, disorder in which one or both of the testes do not descend spontaneously to the usual position in the scrotum. (The testes normally descend around the time of the male infant's birth.) Usually only one testis fails to descend into the scrotum; the other, descended testis suffices to ensure the individual. Testicular embryonal cell carcinoma is a type of non-seminomatous germ cell tumor.. Epidemiology. Incidence peaks at around 25-30 years. Pathology. It may occur as part of a mixed germ cell tumor (more common and may be present as a component in around 80% of mixed germ cell tumors) or very rarely in pure form Neoplastic mimics or pseudotumors can simulate neoplasms on all levels of analysis- clinical, radiologic, and pathologic--and thus represent particular diagnostic pitfalls for the pathologist that can ultimately lead to therapeutic misdirection. This In contrast, nodular Leydig cell hyperplasia is characteristically multiple, smaller in size (less than 0.5 cm), and accompanied by hyperplasia of Leydig cells in the rest of the testis. l 6 Other differential diagnoses include adrenal rests, malakoplakia composed of von Hansemannâ€™s epithelioid cells containing Michaelis-Gutmann bodies. The American Journal of Surgical Pathology. 1985;9:87-94. Nistal M, Redondo E, Paniagua R. Juvenile granulosa cell tumor of the testis. Archives of Pathology & Laboratory Medicine. 1988;112:1129-1132. Zugor V, Labanaris AP, Witt J, et al. Congenital juvenile granulosa cell tumor of the testis in newborns. Anticancer Research. 2010;30:1731-1734